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Home » Anatomy » Knee Chondrocalcinosis: Understanding the Build-Up of Calcium Crystals in the Knees

Knee Chondrocalcinosis: Understanding the Build-Up of Calcium Crystals in the Knees

Knee Chondrocalcinosis, also known as Calcium Pyrophosphate Deposition Disease (CPPD), is a rheumatic condition characterize by the deposition of calcium pyrophosphate (CPP) crystals in the cartilage of the knee joints. These crystals can cause inflammation and pain, and in some cases, can lead to joint damage.


The exact cause of knee chondrocalcinosis is unknown, but it is more common in older adults and people with certain underlying medical conditions, such as hypothyroidism, hyperparathyroidism, and ochronosis. Other risk factors include gout, kidney disease, and pseudogout.


The symptoms of knee chondrocalcinosis can vary from person to person. Some people may have no symptoms at all, while others may experience pain, swelling, stiffness, and redness in the affected knee joints. Symptoms may come and go, or they may be constant.


Knee chondrocalcinosis is often diagnosed based on X-ray findings. X-rays will show the presence of calcium deposits in the cartilage of the knee joints. In some cases, a joint aspiration may be perform to remove synovial fluid from the knee joint. This fluid can then be analyze for the presence of CPP crystals.


There is no cure for knee chondrocalcinosis, but there are treatments that can help to manage the symptoms. These treatments may include:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs): These drugs can help to reduce pain and inflammation.
  • Colchicine: This medication can be use to prevent or shorten the duration of flare-ups.
  • Intra-articular corticosteroid injections: These injections can provide temporary relief from pain and inflammation.
  • Surgery: In some cases, surgery may be necessary to remove calcium deposits or to repair damaged cartilage.


What is the difference between knee chondrocalcinosis and osteoarthritis?

Knee chondrocalcinosis and osteoarthritis are both conditions that affect the knee joints, but they are caused by different things. Knee chondrocalcinosis is caused by the deposition of calcium crystals in the cartilage, while osteoarthritis is caused by the wear and tear of cartilage over time.

Is knee chondrocalcinosis serious?

Knee chondrocalcinosis can be a serious condition, especially if it leads to joint damage. However, with proper treatment, most people with knee chondrocalcinosis can manage their symptoms and live a normal life.

How can I prevent knee chondrocalcinosis?

There is no guaranteed way to prevent knee chondrocalcinosis, but there are some things you can do to reduce your risk, such as:

  • Maintaining a healthy weight
  • Eating a healthy diet
  • Exercising regularly
  • Managing underlying medical conditions

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